Understanding Antibiotic Resistance Mechanisms

Image credit: britannica.com

What are the mechanisms of antibiotic resistance?

In this Review, Blair, Webber and colleagues explore our understanding of the mechanisms of antibiotic resistance, including reduced permeability, antibiotic efflux, modification or alteration of the antibiotic target, modification or destruction of the drug itself, and bypass of metabolic pathways.

What is antibiotic resistance?

antibiotic resistance, loss of susceptibility of bacteria to the killing (bacteriocidal) or growth-inhibiting (bacteriostatic) properties of an antibiotic agent. When a resistant strain of bacteria is the dominant strain in an infection, the infection may be untreatable and life-threatening.

Are antimicrobial resistance mechanisms relevant?

Given the severity of infections caused by these bacteria, their less susceptibility to the available antimicrobials, and the limited antimicrobial arsenal to treat these pathogens, current insight on resistance mechanisms becomes timely and highly relevant.

What are antibiotic resistance mechanisms?

Antibiotic resistance mechanisms are broadly categorized into four strategies, viz., modification of the antibiotic, prevent the antibiotic from reaching its target site, changes and/or bypass of target sites, and biofilm based antibiotic resistance (Benveniste & Davies, 1973; Alekshun & Levy, 2007; Beceiro et al., 2013; Wright, 2016 ).

How is antibiotic resistance encoded?

Antibiotic resistance is encoded by several genes, many of which can transfer between bacteria. New resistance mechanisms are constantly being described, and new genes and vectors of transmission are identified on a regular basis.

What are the mechanisms of antibiotic resistance mediated by target protection?

Schematic diagram of antibiotic resistance mechanisms mediated by target protection, drug inactivation and target bypass. a, Mechanisms of target protection. Target protection proteins can bind to the drug target and sterically remove the drug from the target (part a ,i).

What Is Antibiotic Resistance Mechanisms

1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6604941/
2. https://www.britannica.com/science/antibiotic-resistance
3. https://www.cdc.gov/drugresistance/about/how-resistance-happens.html
4. https://www.who.int/news-room/fact-sheets/detail/antimicrobial-resistance
5. https://www.nature.com/articles/s41579-022-00820-y
6. https://www.microbiologyresearch.org/content/journal/acmi/10.1099/acmi.ac2021.po0053

Antibiotic Resistance Mechanisms Information

1. https://link.springer.com/referenceworkentry/10.1007/978-981-19-9279-7_28
2. https://pubmed.ncbi.nlm.nih.gov/36411397/
3. https://www.reactgroup.org/toolbox/understand/antibiotic-resistance/resistance-mechanisms-in-bacteria/