Cyclic Lipopeptides Antibiotics: Uses and Side Effects

Cyclic lipopeptides are a class of antibiotics that consist of a cyclic peptide linked to a fatty acid chain. They exhibit potent antibacterial activity against a wide range of gram-positive bacteria.

Cyclic Lipopeptides FAQ

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What are cyclic lipopeptides?

Anyone you share the following link with will be able to read this content: The cyclic lipopeptides comprise a number of clinically relevant classes of antibiotics that date back from the discovery of the polymyxins in 1947 to the recent introduction of the semi-synthetic lipoglycopeptides.

What are cyclic lipopeptide antibiotics?

Each of these three is heavily relied upon in the treatment of serious, and often multi-drug resistant, systemic infections caused by both Gram-positive and Gram-negative pathogens. The cyclic lipopeptide antibiotics are generally poorly bioavailable via oral administration, restricting therapies to intravenous administration.

How many cyclic lipodepsipeptides are there?

Although initial analysis of the natural products mixture isolated from the fermentation broth showed the presence of at least 10 compounds, five cyclic lipodepsipeptides were isolated and subsequently named LI-F03, F04, F05, F07 and F08. It was also found that each isolated product contains a mixture of two homologous components .

What are cyclic lipodepsipeptides?

Future perspective Cyclic lipodepsipeptides belong to a large and diverse family of nonribosomally synthesized peptides that have a wide variety of important biological activities.

What are cyclic lipopeptides with long fatty acid side chains?

Cyclic lipopeptides with long fatty acid side chains are a common group of natural products synthesized by a range of bacterial genera (Arima et al., 1968; Cochrane & Vederas, 2016 ). Cyclic lipopeptides typically possess fatty acids with β-hydroxy or β-amino residues and form macrolactone and macrolactam rings (Figure 1 ).

Can cyclic lipopeptides have a localized flexible region?

However, by introducing a flexible residue (i.e., O 2 Oc) into the structure, it was possible to create a localized flexible region. Colistin and other cyclic lipopeptides naturally contain fatty acid tails that are essential for their antimicrobial activity.