Elvitegravir - HIV Medication Overview

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What is Elvitegravir (EVG)?

Elvitegravir ( EVG) is an integrase inhibitor used to treat HIV infection. It was developed by the pharmaceutical company Gilead Sciences, which licensed EVG from Japan Tobacco in March 2008.

Does elvitegravir cure HIV?

HIV is the virus that causes acquired immune deficiency syndrome (AIDS). This medicine is used in patients who are already taking or have received HIV medicines in the past. Elvitegravir will not cure or prevent HIV infection or AIDS, however, it helps keep HIV from reproducing and appears to slow down the destruction of the immune system.

What does elvitegravir do?

Elvitegravir is an HIV-1 integrase strand transfer inhibitor (INSTI). Integrase is an HIV-1 encoded enzyme that is required for viral replication. Inhibition of integrase prevents the integration of HIV-1 DNA into host genomic DNA, blocking the formation of the HIV-1 provirus and propagation of the viral infection.

Can elvitegravir cause an infection?

If you have an infection that you did not know you had, it may show up when you take elvitegravir. Tell your doctor right away if you have any new signs after you start elvitegravir, even after taking it for several months. This includes signs of infection like fever, sore throat, weakness, cough, or shortness of breath .

Does elvitegravir inhibit integrase?

Integrase is an HIV-1 encoded enzyme that is required for viral replication. Inhibition of integrase prevents the integration of HIV-1 DNA into host genomic DNA, blocking the formation of the HIV-1 provirus and propagation of the viral infection. Elvitegravir does not inhibit human topoisomerases I or II.

What Is Elvitegravir

1. https://en.wikipedia.org/wiki/Elvitegravir
2. https://www.drugs.com/cdi/elvitegravir.html
3. https://go.drugbank.com/drugs/DB09101
4. https://www.medicine.com/drug/elvitegravir
5. https://clinicalinfo.hiv.gov/en/drugs/elvitegravir-cobicistat-emtricitabine-tenofovir-disoproxil-fumarate/patient
6. https://www.mayoclinic.org/drugs-supplements/elvitegravir-oral-route/description/drg-20122617
7. https://my.clevelandclinic.org/health/drugs/20644-elvitegravir-cobicistat-emtricitabine-tenofovir-oral-tablets

Elvitegravir Information

1. https://www.tga.gov.au/sites/default/files/auspar-elvitegravir-131216-pi.pdf
2. https://www.tandfonline.com/doi/full/10.2147/HIV.S20993
3. https://www.aidsmap.com/about-hiv/arv-background-information/elvitegravir
4. https://www.mskcc.org/cancer-care/patient-education/medications/adult/elvitegravir