mRNA-Based Therapies: Potential Benefits

mRNA-based therapies involve the use of messenger RNA (mRNA) to instruct cells in the body to produce proteins that can help prevent or fight diseases, such as cancer or infectious diseases.
Category
Therapy
Where to get
Research and development ongoing in the field of mRNA-based treatments.
Applicable for
Various Diseases
Prepared by Shruti Sahoo, reviewed by Dr. Eugene Smith

MRNA-based Therapies FAQ


Image credit: the-dna-universe.com

What is mRNA based therapy?

At the fundamental level, messenger RNA (mRNA)-based therapeutics involves the delivery of in vitro-transcribed (IVT) mRNA into the cytoplasm of a target cell, where it is translated into the desired protein. IVT mRNA presents various advantages compared to DNA and recombinant protein-based approach …

What is mRNA therapeutics?

The concept of mRNA therapeutics is quite simple, which uses in vitro transcribed mRNA to direct the translation of proteins with pharmacological activity in vivo. Since mRNA carries the message of any gene, it can theoretically produce almost any functional protein/peptide for vaccination or protein replacement therapy.

What are the different types of mRNA therapeutics?

Based on the application areas, the current mRNA therapeutics can roughly be divided into three basic categories, the prophylactic vaccines against infectious diseases, the therapeutic vaccines against cancers, and the protein-replacement medicines either as direct immune therapies or as other protein drugs.

Can mRNA be used as a new therapeutic?

Being one of the key macromolecules, the messenger RNA (mRNA) also has the potential to be applied as new therapeutics. The concept of mRNA therapeutics is quite simple, which uses in vitro transcribed mRNA to direct the translation of proteins with pharmacological activity in vivo.

MRNA-based Therapies References

If you want to know more about MRNA-based Therapies, consider exploring links below:

What Is MRNA-based Therapies

  1. https://www.nature.com/articles/s41392-022-01007-w
  2. https://en.wikipedia.org/wiki/RNA_Therapeutics
  3. https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(23)02444-3/fulltext
  4. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9123296/

MRNA-based Therapies Information

  1. https://www.sciencedirect.com/science/article/pii/S2667325823000729
  2. https://pubs.acs.org/doi/10.1021/acsptsci.3c00047
  3. https://www.thermofisher.com/blog/behindthebench/mrna-therapies-current-landscape-and-future-possibilities/
  4. https://theconversation.com/customizing-mrna-is-easy-and-thats-what-makes-it-the-next-frontier-for-personalized-medicine-a-molecular-biologist-explains-216127
  5. https://pubmed.ncbi.nlm.nih.gov/36064262/

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