Penicillin-binding Proteins in Bacteria

Penicillin-binding proteins (PBPs) are bacterial proteins that play a crucial role in the cell wall synthesis of bacteria. They are the target of beta-lactam antibiotics like penicillins and cephalosporins.
Category
Protein
Where to get
N/A
Prepared by Shruti Sahoo, reviewed by Dr. Eugene Smith

Penicillin-binding Proteins FAQ


Image credit: pdb101.rcsb.org

What are penicillin-binding proteins?

Erin E. Carlson, in Methods in Enzymology, 2020 Penicillin-binding proteins (PBPs) are membrane-associated proteins involved in the biosynthesis of peptidoglycan (PG), the main component of bacterial cell walls. These proteins were discovered and named for their affinity to bind the β-lactam antibiotic penicillin.

What are penicillin-binding proteins (PBPs)?

(NAM = N-acetylmuramic acid; NAG = N-acetylglucosamine) Penicillin-binding proteins ( PBP s) are a group of proteins that are characterized by their affinity for and binding of penicillin. They are a normal constituent of many bacteria; the name just reflects the way by which the protein was discovered.

Why do penicillin-binding proteins bind -lactam antibiotics?

Penicillin-binding proteins are generally enzymes involved in peptidoglycan biosynthesis, so contribute essential roles in bacterial cell wall biosynthesis. PBPs bind β-lactam antibiotics because their chemical structure is similar to that of the sugar–amino acid backbone that forms peptidoglycan.

How does penicillin interact with a bacterial cell?

Interaction of penicillin with the bacterial cell: penicillin-binding proteins and penicillin-sensitive enzymes. Distinct penicillin-binding proteins involved in the division, elongation, and shape of Escherichia coli K12. Penicillin-binding proteins and cell shape in Escherichia coli.

Penicillin-binding Proteins References

If you want to know more about Penicillin-binding Proteins, consider exploring links below:

Explore Related Topics

What Makes Cephalosporins Broad-Spectrum Antibiotics?

Uncover the reasons behind cephalosporins being classified as broad-spectrum antibiotics. Share your knowledge on the spectrum of activity and applications of cephalosporins in clinical practice.

Recommended Links

Here is the references to the suggested products and services from our partners: