Penicillin-binding Proteins in Bacteria

Penicillin-binding proteins (PBPs) are bacterial proteins that play a crucial role in the cell wall synthesis of bacteria. They are the target of beta-lactam antibiotics like penicillins and cephalosporins.
Category
Protein
Where to get
N/A
Applicable for
Bacterial Cell Wall Synthesis
Prepared by Shruti Sahoo, reviewed by Dr. Eugene Smith

Penicillin-binding Proteins FAQ


Image credit: pdb101.rcsb.org

What are penicillin-binding proteins?

Erin E. Carlson, in Methods in Enzymology, 2020 Penicillin-binding proteins (PBPs) are membrane-associated proteins involved in the biosynthesis of peptidoglycan (PG), the main component of bacterial cell walls. These proteins were discovered and named for their affinity to bind the β-lactam antibiotic penicillin.

What are penicillin-binding proteins (PBPs)?

(NAM = N-acetylmuramic acid; NAG = N-acetylglucosamine) Penicillin-binding proteins ( PBP s) are a group of proteins that are characterized by their affinity for and binding of penicillin. They are a normal constituent of many bacteria; the name just reflects the way by which the protein was discovered.

Why do penicillin-binding proteins bind -lactam antibiotics?

Penicillin-binding proteins are generally enzymes involved in peptidoglycan biosynthesis, so contribute essential roles in bacterial cell wall biosynthesis. PBPs bind β-lactam antibiotics because their chemical structure is similar to that of the sugar–amino acid backbone that forms peptidoglycan.

How does penicillin interact with a bacterial cell?

Interaction of penicillin with the bacterial cell: penicillin-binding proteins and penicillin-sensitive enzymes. Distinct penicillin-binding proteins involved in the division, elongation, and shape of Escherichia coli K12. Penicillin-binding proteins and cell shape in Escherichia coli.

Penicillin-binding Proteins References

If you want to know more about Penicillin-binding Proteins, consider exploring links below:

What Is Penicillin-binding Proteins

  1. https://en.wikipedia.org/wiki/Penicillin-binding_proteins
  2. https://www.sciencedirect.com/topics/neuroscience/penicillin-binding-protein
  3. https://academic.oup.com/femsre/article/30/5/673/2398954
  4. https://www.nature.com/subjects/penicillin-binding-proteins
  5. https://www.clinicalmicrobiologyandinfection.com/article/S1198-743X(15)30272-X/fulltext
  6. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4331424/

Penicillin-binding Proteins Information

  1. https://journals.sagepub.com/doi/10.1177/15353702231208407

Explore Related Topics

Antibiotics Overview / Types of Antibiotics

What Makes Cephalosporins Broad-Spectrum Antibiotics?

Uncover the reasons behind cephalosporins being classified as broad-spectrum antibiotics. Share your knowledge on the spectrum of activity and applications of cephalosporins in clinical practice.

Read 20 answer(s)
2024-Mar-21 12:48