Pritelivir Investigational Antiviral Drug
Pritelivir FAQ
Is Pritelivir a direct-acting antiviral drug?
Pritelivir is a direct-acting antiviral drug in development for the treatment of herpes simplex virus infections (HSV). This is particularly important in immune compromised patients . Pritelivir is currently in Phase III clinical development by the German biopharmaceutical company AiCuris Anti-infective Cures AG .
What is Pritelivir used for?
AiCuris develops Pritelivir oral tablets for the treatment of acyclovir-resistant mucocutaneous HSV infections. As an active ingredient in a new chemical class ( thiazolylamides ), pritelivir is active against both HSV ( HSV-1 and HSV-2) types that cause genital or cold sores.
Who makes Pritelivir?
Pritelivir is currently in Phase III clinical development by the German biopharmaceutical company AiCuris Anti-infective Cures AG . US FDA granted Fast Track Designation for pritelivir in 2017. US FDA granted Breakthrough Therapy Designation for pritelivir in 2020. Pritelivir is also known as AIC316 or BAY 57-1293.
Is Pritelivir safe?
Considering a therapeutic dose of 100 mg once daily, Pritelivir demonstrated a favorable safety, tolerability, and pharmacokinetic profile in healthy subjects to support further development. Based on these positive results, AiCuris form the basis for regulatory approval.
Why was Pritelivir discovered?
The discovery of pritelivir resulted from systematic research rather than an accidental discovery. Pritelivir does not require activation by viral enzymes and can thus protect uninfected cells. AiCuris develops Pritelivir oral tablets for the treatment of acyclovir-resistant mucocutaneous HSV infections.
Is Pritelivir effective in treating genital herpes?
This study shows that pritelivir, the first in a new class of antiviral agents developed for the treatment of herpes simplex infections, is effective in suppressing viral shedding and lesion development in patients with genital herpes.
Pritelivir References
If you want to know more about Pritelivir, consider exploring links below:
What Is Pritelivir
- https://www.precisionvaccinations.com/vaccines/pritelivir-aic316-herpes-treatment-2023
- https://en.wikipedia.org/wiki/Pritelivir
- https://www.sciencedirect.com/topics/medicine-and-dentistry/pritelivir
- https://www.europeanpharmaceuticalreview.com/news/158183/phase-iii-trial-to-assess-pritelivir-as-a-treatment-for-herpes-simplex-virus-infections/
- https://www.nejm.org/doi/full/10.1056/NEJMoa1301150
- https://medicalxpress.com/news/2021-06-tweak-pritelivir-treatment-latent-herpes.html
- https://www.yalemedicine.org/clinical-trials/pritelivir-versus-foscarnet-for-the-treatment-of-acyclovir-resistant-mucocutaneous-hsv-prioh-1
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9620171/
- https://pubs.acs.org/doi/10.1021/acs.jmedchem.2c00668