Sotrovimab - Monoclonal Antibody Treatment for COVID-19

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What are the side effects of sotrovimab?

It was developed by GlaxoSmithKline and Vir Biotechnology, Inc. Sotrovimab is designed to attach to the spike protein of SARS-CoV-2. The most common side effects include hypersensitivity (allergic) reactions and infusion-related reactions.

How does sotrovimab work?

Sotrovimab has demonstrated activity via two antiviral mechanisms in vitro, antibody-dependent cellular cytotoxicity (ADCC) and antibody-dependent cellular phagocytosis (ADCP).

Does sotrovimab reduce hospitalisation or death?

According to a Government press release, sotrovimab has been shown to reduce hospitalisation or death by 79% in adults with mild-to-moderate COVID-19 who are at high risk of progression to severe disease. But what exactly is sotrovimab? Sotrovimab is a novel monoclonal antibody treatment.

When is sotrovimab given?

Sotrovimab is given by intravenous infusion, preferably within 5 days of onset of COVID-19 symptoms. Sotrovimab's development began in December 2019, at Vir Biotechnology when Vir scientists first learned of the initial COVID-19 outbreak in China.

What is sotrovimab?

But what exactly is sotrovimab? Sotrovimab is a novel monoclonal antibody treatment. The laboratory-made proteins are designed to mimic the natural antibodies produced by the immune system when defending itself against diseases.

How many ml of sotrovimab are in a vial?

Each vial contains 500 mg of sotrovimab in 8 mL (62.5 mg/mL). For the full list of excipients, see Section 6.1 LIST OF EXCIPIENTS. Sotrovimab is a clear, colourless or yellow to brown concentrated injection solution for intravenous infusion.

What Is Sotrovimab

1. https://en.wikipedia.org/wiki/Sotrovimab
2. https://www1.racgp.org.au/newsgp/clinical/what-is-the-covid-19-treatment-sotrovimab
3. https://www.drugs.com/mtm/sotrovimab.html
4. https://theconversation.com/what-is-sotrovimab-the-covid-drug-the-government-has-bought-before-being-approved-for-use-in-australia-165802
5. https://www.tga.gov.au/news/news/covid-19-treatment-glaxosmithkline-australia-pty-ltd-sotrovimab-xevudy
6. https://www.health.gov.au/ministers/the-hon-greg-hunt-mp/media/tga-approves-new-covid-19-treatment-for-use-in-australia
7. https://nswtag.org.au/wp-content/uploads/2021/08/3.-GUIDELINE-for-use-of-SOTROVIMAB-in-COVID-19_VersionPrelim_28Aug21.pdf
8. https://www.nejm.org/doi/full/10.1056/NEJMoa2107934
9. https://www.nhs.uk/medicines/sotrovimab/

Sotrovimab Information

1. https://www.sotrovimab.com/
2. https://www.cec.health.nsw.gov.au/__data/assets/pdf_file/0004/717007/Information-for-patients-family-and-carers-Sotrovimab-Factsheet.PDF
3. https://au.gsk.com/en-au/media/press-releases/first-monoclonal-antibody-treatment-approved-for-covid-19-in-australia/
4. https://monashhealth.org/wp-content/uploads/2021/12/Sotrovimab-Patient-Information-FINAL-1.pdf