Streptogramins - Antibiotics for Skin and Bloodstream Infections

Streptogramins are a combination of two antibiotics that inhibit bacterial protein synthesis by acting on the 50S ribosomal subunit.

Streptogramins FAQ

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What are streptogramins?

Streptogramins are a type of antibiotic that inhibit protein synthesis in bacteria by binding to the 50S ribosomal sub-unit, in a similar way to macrolides and lincosamides. They are produced naturally by certain subspecies of Streptomyces bacteria.

How do streptogramins work?

Streptogramins are a class of antibiotics that work by inhibiting the synthesis of protein in bacteria. There are two types of streptogramins: streptogramin A (dalfopristin) and streptogramin B (quinupristin). Individually, both A and B streptogramins inhibit bacterial growth ( bacteriostatic ).

Are Streptogramins A class of antibiotics?

Streptogramins are a class of antibiotics. Streptogramins are effective in the treatment of vancomycin-resistant Staphylococcus aureus (VRSA) and vancomycin-resistant Enterococcus (VRE), two of the most rapidly growing strains of multidrug-resistant bacteria. They fall into two groups: streptogramin A and streptogramin B. [citation needed]

How many types of Streptogramins are there?

There are two types of streptogramins: streptogramin A (dalfopristin) and streptogramin B (quinupristin). Individually, both A and B streptogramins inhibit bacterial growth ( bacteriostatic ). However, when combined, streptogramins A and B kill bacteria (bactericidal).

Are streptogramins produced naturally?

They are produced naturally by certain subspecies of Streptomyces bacteria. Streptogramins include two structurally unrelated components, streptogramin group A (dalfopristin) and streptogramin group B (quinupristin).