Synergistic Antibiotic-antiviral Combinations - Dual Action Against Infections

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What are synergistic antibiotic combinations?

Fig. 1: Classification of synergistic antibiotic combinations. In a congruous pair, two antibiotics (A and B) that target distinct essential molecular processes can display synergy.

What is synergy between antibiotics?

Synergy between antibiotics is a strictly defined microbiological phenomenon, requiring two bioactive agents to exhibit enhanced bacterial killing when the two are combined. Because of increasing antibiotic resistance, and few new drugs to treat multidrug-resistant bacteria, combination therapy is often used in the clinical setting.

Can antibacterial combinations improve antibiotic efficacy and suppress antibacterial resistance?

Antibacterial combinations can improve antibiotic efficacy and suppress antibacterial resistance through independent, synergistic, or even antagonistic activities. Combination therapies are famously used to treat viral and mycobacterial infections and cancer.

Are synergistic congruous antibiotic combinations effective?

The unnecessary antibiotic exposure in instances of unregulated combinations, and the lack of rapid, reliable diagnostics to guide the clinician in initial therapy, are issues that can be managed with tighter regulatory controls and innovation in molecular diagnostics. However, what remain effective are synergistic congruous combinations.

Which drug combinations have strong synergy in vitro?

From this empirical set of 30 tested combinations, we discovered two drug combinations (remdesivir and reserpine; remdesivir and IQ-1S) with strong synergy in vitro. In general, ComboNet represents an advance toward predicting novel chemical−chemical synergy for instances where minimal combination training data exist.

Are syncretic combinations of antibiotics and non-antibiotic adjuvants a good idea?

Syncretic combinations of antibiotics with non-antibiotic adjuvants offer a very promising area for antibiotic discovery and development. In an era when new antibiotic innovation is at a nadir, reinvigorating our existing antibiotic drug classes provides an excellent opportunity to extend the life of well-researched and clinically validated drugs.

What Is Synergistic Antibiotic-antiviral Combinations

1. https://www.nature.com/articles/s41579-018-0141-x
2. https://link.springer.com/chapter/10.1007/7355_2017_23
3. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8905495/
4. https://www.sciencedirect.com/science/article/pii/S1369527420300710
5. https://nyaspubs.onlinelibrary.wiley.com/doi/full/10.1111/nyas.14649
6. https://pubmed.ncbi.nlm.nih.gov/22628215/
7. https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2022.849006/full

Synergistic Antibiotic-antiviral Combinations Information

1. https://www.pnas.org/doi/full/10.1073/pnas.2105070118?doi=10.1073/pnas.2105070118