Antiretroviral Drug Resistance - Challenges and Implications
Antiretroviral Medication Resistance FAQ
Does contemporary antiretroviral therapy lead to HIV drug resistance?
Contemporary antiretroviral therapy (ART) regimens have high barriers to the development of drug resistance. However, resistance to earlier antiretrovirals and uncommon cases of resistance to contemporary ART illustrate the continued need for good clinical management of HIV drug resistance.
Are antiretroviral drugs causing a high rate of drug resistance?
Highly active antiretroviral (ARV) therapy has been used for many years, but the use in low- and middle-income countries of antiretroviral drugs with low genetic barrier to resistance, combined with limited availability of viral load testing, has led to higher rates of acquired drug resistance, sustaining the rate of transmitted drug resistance.
How common is HIV drug resistance to non-nucleoside reverse transcriptase inhibitors?
Pretreatment HIV drug resistance to the non-nucleoside reverse transcriptase inhibitors (NNRTI) drug class is up to 3 times more common in people with previous exposure to antiretroviral drugs. Nearly one half of infants born to mothers infected with HIV has HIV drug resistance to one or more NNRTIs.
How common is HIV drug resistance?
Up to 10% of adults starting HIV treatment can have drug resistance to the non-nucleoside reverse transcriptase inhibitors (NNRTI) drug class. Pretreatment NNRTI resistance is up to 3 times more common in people with previous exposure to antiretroviral drugs.
Antiretroviral Medication Resistance References
If you want to know more about Antiretroviral Medication Resistance, consider exploring links below:
What Is Antiretroviral Medication Resistance
- https://www.who.int/news-room/fact-sheets/detail/hiv-drug-resistance
- https://www.webmd.com/hiv-aids/hiv-drug-resistance
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9967014/
- https://www.healthdirect.gov.au/hiv-and-aids-medicines
- https://www.nejm.org/doi/full/10.1056/NEJMra1004180