Collagen Synthesis Mechanism and Importance

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Where does collagen synthesis occur?

The process of collagen synthesis occurs mainly in the cells of fibroblasts which are specialized cells with the main function of synthesizing collagen and stroma. Collagen synthesis occurs both intracellularly and extracellularly.

Which type of tissue is formed during collagen synthesis?

This type of tissue has two different characteristics: synthesis of Type III collagen formation in the tissue matrix, and formation of new vascular network, which is called neovascularization. As discussed previously, the type of collagen formed during collagen synthesis depends on the chemical makeup of the procollagen molecule.

How is collagen synthesis calculated?

The percent collagen synthesis is calculated from the CDP and NCP values after correcting for the greater abundance of proline in collagen relative to noncollagen proteins . Collagen production can also be determined by measuring the hydroxyproline content of cell or organ cultures, since hydroxyproline is virtually unique to collagens.

What is collagen synthesis?

Schematic representation of collagen synthesis starting form the nuclear transcription of the collagen genes, mRNA processing, ribosomal protein synthesis (translation) and post-translational modifications, secretion and the final steps of fibril formation. (SP: signal

Does collagen synthesis occur intracellular or extracellularly?

Collagen synthesis occurs both intracellularly and extracellularly. Although different types of collagen may undergo different post-translational modifications, the basic outline for collagen synthesis is listed below. As with any biochemical pathway, there are numerous steps that are carefully executed and are tightly regulate and controlled.

How is collagen synthesis based on gene transcription?

The biosynthesis of collagens starting with gene transcription of the genes within the nucleus to the aggregation of collagen heterotrimers into large fibrils is a complex multistep process (Fig. 3). Since most of our knowledge of these mechanisms is based on fibril-forming collagens, this discussion will mostly focus on type I collagen.

What Is Collagen Synthesis

1. https://www.ncbi.nlm.nih.gov/books/NBK507709/
2. https://en.wikipedia.org/wiki/Collagen
3. https://my.clevelandclinic.org/health/articles/23089-collagen
4. https://www.sciencedirect.com/topics/medicine-and-dentistry/collagen-synthesis
5. https://www.news-medical.net/health/Collagen-Synthesis.aspx
6. https://www.hsph.harvard.edu/nutritionsource/collagen/

Collagen Synthesis Information

1. https://www.researchgate.net/publication/9004464_Collagens-Structure_function_and_biosynthesis
2. https://link.springer.com/chapter/10.1007/978-94-007-7893-1_2
3. https://www.nature.com/articles/s41467-022-34127-6