Understanding Combination Therapy in Healthcare

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What is combination drug therapy?

Bree Aldridge: Combination drug therapy is simply using drugs together with the purpose of increasing efficacy. There are a lot of diseases treated with combination therapy, including tuberculosis, HIV, and many cancers.

What is a combination treatment approach?

One combination treatment approach is to coadminister drugs that work by different molecular mechanisms, thereby increasing tumor cell killing while reducing the likelihood of drug resistance and minimizing overlapping toxicity.

What is combination therapy in cancer treatment?

Combination therapy, a treatment modality that combines two or more therapeutic agents, is a cornerstone of cancer therapy. The amalgamation of anti-cancer drugs enhances efficacy compared to the mono-therapy approach because it targets key pathways in a characteristically synergistic or an additive manner.

What is a combination therapy?

While it typically denotes the use of two or more drugs, it can also include immunotherapy, nonmedical therapies, including psychological therapy, and other means of therapy or treatment. The practice may not be new, but there has been a large increase in the number of approved and researched combination therapies over the past decade.

Is combination therapy better than monotherapy?

Use of combination therapy is sought out as a superior approach to treat different cancers as compared to monotherapy. Combination therapy has been found to achieve higher efficacy with lower doses of less toxic drugs, or even lower doses of toxic drugs, with much better results.

What conditions can be treated with combination therapy?

Conditions treated with combination therapy include tuberculosis, leprosy, cancer, malaria, and HIV / AIDS. One major benefit of combination therapies is that they reduce development of drug resistance since a pathogen or tumor is less likely to have resistance to multiple drugs simultaneously.

What Is Combination Therapy

1. https://en.wikipedia.org/wiki/Combination_therapy
2. https://www.verywellhealth.com/what-is-combination-chemotherapy-2248995
3. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5514969/
4. https://www.msdmanuals.com/en-gb/home/cancer/prevention-and-treatment-of-cancer/combination-cancer-therapy
5. https://www.sciencedirect.com/science/article/pii/B9780128205761000011
6. https://now.tufts.edu/2022/01/14/what-combination-drug-therapy
7. https://blog.dana-farber.org/insight/2016/11/what-is-combination-therapy/

Combination Therapy Information

1. https://link.springer.com/article/10.1007/s12672-023-00758-4
2. https://www.nature.com/articles/s41586-022-04437-2
3. https://bmcmedicine.biomedcentral.com/articles/10.1186/s12916-023-02852-4