Daptomycin: Mechanism of Action and Indications
Daptomycin FAQ
What is daptomycin used for?
The World Health Organization classifies daptomycin as critically important for human medicine. In the United States, daptomycin is indicated for use in adults for skin and skin structure infections caused by Gram-positive infections, S. aureus bacteraemia, and right-sided S. aureus endocarditis.
How does daptomycin kill bacterial cells?
Daptomycin is a cyclic lipopeptide antibiotic that has a unique mechanism of action. It binds to the bacterial cell membranes, causing rapid depolarization of the membrane due to potassium efflux and associated disruption of DNA, RNA, and protein synthesis; the result is rapid concentration-dependent bacterial death.
Is daptomycin a Gram-positive antimicrobial?
Literature review current through: Jan 2024. This topic last updated: Mar 07, 2023. Daptomycin is a lipopeptide antimicrobial with activity against gram-positive organisms, including antimicrobial-resistant pathogens such as methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus spp [ 1,2 ].
Is daptomycin a cyclic lipopeptide?
Daptomycin is a cyclic lipopeptide antibiotic produced by Streptomyces roseosporus. Daptomycin consists of 13 amino acids, 10 of which are arranged in a cyclic fashion, and three on an exocyclic tail.
How does daptomycin affect a cell?
It alters the shape of the membrane to form a hole, allowing ions in and out of the cell easily. Daptomycin, sold under the brand name Cubicin among others, is a lipopeptide antibiotic used in the treatment of systemic and life-threatening infections caused by Gram-positive organisms.
Daptomycin References
If you want to know more about Daptomycin, consider exploring links below:
What Is Daptomycin
- https://www.drugs.com/mtm/daptomycin.html
- https://en.wikipedia.org/wiki/Daptomycin
- https://www.ncbi.nlm.nih.gov/books/NBK470407/
- https://www.merckmanuals.com/professional/infectious-diseases/bacteria-and-antibacterial-drugs/daptomycin
- https://www.uptodate.com/contents/daptomycin-an-overview
- https://medlineplus.gov/druginfo/meds/a608045.html
- https://www.healthdirect.gov.au/medicines/brand/amt,1638031000168104/daptomycin-pfizer
- https://www.mayoclinic.org/drugs-supplements/daptomycin-intravenous-route/description/drg-20063292
- https://www.msdmanuals.com/en-au/home/infections/antibiotics/daptomycin
Daptomycin Information
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