Effective Treatments for Multidrug-Resistant Infections

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What is multidrug resistance?

This is also called cross-resistance. Infections with multidrug-resistant bacteria are hard to treat since few or even no treatment options remain. In some cases health care providers have to use antibiotics that are more toxic for the patient. Multidrug-resistance facilitates spread of antibiotic resistance.

What are new anti-infectious strategies against multidrug-resistant and persistent bacteria?

In this context, new anti-infectious strategies against multidrug-resistant (MDR) and persistent bacteria, as well as the rescue of Food and Drug Administration (FDA)-approved compounds (drug repurposing), are being explored.

Can'rescuing' drugs help fight persistent infections?

Given the time involved and economic problems associated with the development of a new drugs, “rescuing” drugs already approved by the FDA that exhibit antibacterial activity is another possible option for fighting persistent infections.

What is multi-drug resistance?

Multi-drug resistance is defined as non-susceptibility to at least one antimicrobial in three or more classes as tested with in vitro susceptibility testing [ 8 ].

What is multidrug resistant organism (MDRO)?

Multidrug resistant organism (MDRO) infections cause prolonged hospitalization, excess morbidities and mortalities, and subsequently contribute to huge economic burdens. 1 Multidrug resistance is one of the top threats to global health.

What is the best treatment for MDR Gram-negative infections?

These agents include colistin, fosfomycin, tigecycline, aminoglycosides, piperacillin/tazobactam and high-dose carbapenems. The optimal use of colistin in MDR Gram-negative infections is subject to debate.

What Is Multidrug-resistant Infection Treatments

1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9633024/
2. https://www.cdc.gov/hai/mdro-guides/index.html
3. https://www.who.int/news-room/fact-sheets/detail/antimicrobial-resistance
4. https://academic.oup.com/jac/article/76/Supplement_4/iv23/6437935
5. https://www.sciencedirect.com/science/article/pii/S1684118222000251
6. https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2022.972935/full
7. https://www.reactgroup.org/toolbox/understand/antibiotic-resistance/multidrug-resistant-bacteria/

Multidrug-resistant Infection Treatments Information

1. https://pubmed.ncbi.nlm.nih.gov/35370082/
2. https://link.springer.com/content/pdf/10.1007/s11739-021-02749-1.pdf