Virazole (Ribavirin): Uses and Administration

Virazole, also known as ribavirin, is an antiviral medication used to treat severe respiratory syncytial virus (RSV) infection in infants and young children. It inhibits viral RNA synthesis, interfering with viral replication.
Category
Drug
Where to get
Administered in hospital settings under medical supervision.
Prepared by Shruti Sahoo, reviewed by Dr. Eugene Smith

Virazole FAQ


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What is Virazole used for?

Virazole is a prescription medicine used to treat the symptoms of Chronic Hepatitis C and Respiratory Syncytial Virus ( RSV) in children. Virazole may be used alone or with other medications. Virazole belongs to a class of drugs called Hepatitis B / Hepatitis C Agents; RSV Agents. What are the possible side effects of Virazole?

How does Virazole (ribavirin) work?

Virazole (ribavirin) is an antiviral medication that works against the respiratory syncytial virus (RSV). It's not clear how the medication treats RSV, but it's thought to stop the virus from making copies of itself in the lungs.

How is Virazole (ribavirin) detected in human materials?

Assay for VIRAZOLE (ribavirin) in human materials is by a radio immunoassay which detects ribavirin and at least one metabolite. VIRAZOLE brand of ribavirin, when administered by aerosol, is absorbed systemically.

What is Virazole ® (ribavirin for inhalation solution)?

VIRAZOLE ® (Ribavirin for Inhalation Solution, USP) is indicated for the treatment of hospitalized infants and young children with severe lower respiratory tract infections due to RSV. Treatment early in the course of severe lower respiratory tract infection may be necessary to achieve efficacy.

What is the recommended treatment regimen for Virazole?

The recommended treatment regimen is 20 mg/mL VIRAZOLE as the starting solution in the drug reservoir of the SPAG-2 unit, with continuous aerosol administration for 12-18 hours per day for 3 to 7 days. Using the recommended drug concentration of 20 mg/mL the average aerosol concentration for a 12 hour delivery period would be 190 mcg/L of air.

Is Virazole overdosed in humans?

No overdosage with VIRAZOLE by aerosol administration has been reported in humans. The LD 50 in mice is 2 g orally and is associated with hypoactivity and gastrointestinal symptoms (estimated human equivalent dose of 0.17 g/kg, based on body surface area conversion).

What are the signs & symptoms of Virazole?

Nearly all were in individuals providing direct care to infants receiving aerosolized VIRAZOLE. Of 358 events from these 152 individual health care worker reports, the most common signs and symptoms were headache (51% of reports), conjunctivitis (32%), and rhinitis, nausea, rash, dizziness, pharyngitis, or lacrimation (10-20% each).

Virazole References

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