Understanding Hepatitis C Genotype 1 Infection: Characteristics and Treatment

Hepatitis C genotype 1 infection refers to a specific strain of the hepatitis C virus found in individuals diagnosed with genotype 1 hepatitis C.

Hepatitis C Genotype 1 Infection FAQ

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What is hepatitis C genotype 1 & 3?

Hepatitis C genotypes 1 and 3 infection are associated with more aggressive liver disease, with increased risk for cirrhosis and fibrosis, as well as greater risk for hepatocellular carcinoma. After genotype 1, HCV genotype 2 is the next most common HCV genotype in the US, where it accounts for approximately 10% of cases.

Which hepatitis C genotype is most common?

HCV genotype 1 is the most common genotype in the US and Europe, accounting for 60% to 70% of HCV. HCV genotype 1a is more common than 1b in the US. 3 Hepatitis C genotypes 1 and 3 infection are associated with more aggressive liver disease, with increased risk for cirrhosis and fibrosis, as well as greater risk for hepatocellular carcinoma.

How are hepatitis C genotypes determined?

A doctor can determine genotypes using blood tests. There are six hepatitis C genotypes, numbered 1–6. There are also subtypes, designated with a letter — for example, 1a or 1b. People with hepatitis C are most likely to carry a single genotype — that of the virus responsible for the initial infection.

Do different hepatitis C genotypes have different responses to treatment?

Many studies have shown that different hepatitis C genotypes have different responses to treatment. IFN and Ribavirin complex regimen is significantly effective among infected patients with genotype 1 (SVR more than 90%).