Combatting Multidrug-resistant Gram-negative Infections

Multidrug-resistant gram-negative infections are challenging to treat due to limited antibiotic options. Infection prevention and antimicrobial stewardship are key strategies.

Multidrug-resistant Gram-negative Infections FAQ

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What is multidrug resistant Gram-negative bacteria (MDRGN)?

Multidrug resistant Gram-negative bacteria ( MDRGN bacteria) are a type of Gram-negative bacteria with resistance to multiple antibiotics. They can cause bacteria infections that pose a serious and rapidly emerging threat for hospitalized patients and especially patients in intensive care units.

Are multidrug-resistant Gram-negative bacteria causing more infections?

In the past years infections caused by multidrug-resistant Gram-negative bacteria have dramatically increased in all parts of the world. This consensus paper is based on presentations, subsequent discussions and an appraisal of current literature by a panel of international experts invited by the Rudolf Schülke Stiftung, Hamburg.

Can Gram-negative bacteria acquire multidrug resistance?

Gram-negative bacteria can acquire resistance to one or more important classes of antibiotics, which usually prove effective against them such as: Third- or fourth-generation cephalosporins (cefotaxime, ceftazidime) Definition of multidrug resistance varies between countries.

What are multi-drug resistant Gram-negative infections?

Multi-drug resistant gram-negative infections, which have emerged as a result of bacterial evolution and inappropriate use of antibiotics, are currently a major area of concern. The FDA has approved a handful of antibiotics in recent years.

What is multidrug-resistant Gram-negative (MDR-GN) infection?

Multidrug-resistant gram-negative (MDR-GN) organisms, defined as organisms nonsusceptible to ≥1 agent in ≥3 antimicrobial categories [ 2 ], pose serious management challenges. Preemptively identifying patients with MDR-GN infections is challenging and is associated with increased morbidity and mortality [ 3, 4 ].